Isaac Guerendo hasn't started a game at running back since the fourth grade. Now he's the 49ers starting running back for the remainder of the season. Here's the good news for the 49ers: In 42 career ...

On the other side of the ball, Isaac Guerendo has been ruled out due to a hamstring injury ... but it's worth noting this was ...

Linebacker Dre Greenlaw was back at practice in a limited capacity on Wednesday following his Week 15 regular season debut.

Backup running Ameer Abdullah is in line to get an increased workout with White and Mattison ... the 49ers' running game will likely center on rookie Isaac Guerendo, who rushed for 99 and 85 ...

RB Isaac Guerendo was dealing with a hamstring injury. Here are the latest updates leading up to Week 17’s game vs. the Lions ...

Guerendo took nine carries for 34 yards while bringing in all four targets for 65 receiving yards in Monday's 40-34 loss to the Lions. Guerendo made a successful return from a one-game layoff due to ...

As the 49ers look to play spoiler against the Lions on Monday Night Football, RB Isaac Guerendo got a positive injury update.

When will Isaac Guerendo return and play? Will Isaac Guerendo be back again this season? Read the latest Isaac Guerendo ...

San Francisco 49ers running back Isaac Guerendo is unlikely to play in Sunday's game against the host Miami Dolphins, ESPN reported Thursday. Guerendo is nursing a foot injury sustained in the ...

The San Francisco 49ers' running backs just can't catch a break. Isaac Guerendo shined in his first career NFL start last week, shredding the Chicago Bears' defense with 128 total yards and two ...

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