Lineup notes on who's in, who's out and which fantasy football starters are questionable for this weekend's games.

Entering a do-or-die matchup vs. the Chicago Bears this Sunday, the San Francisco 49ers are banking on rookie running Isaac Guerendo to fill the shoes left by reigning Offensive Player of the Year ...

“49ers rookie RB Isaac Guerendo plans to play Thursday night vs. the Rams despite his sprained foot that has left him being ...

Well this isn't good. 49ers rookie Isaac Guerendo is nursing a new injury. Kyle Shanahan revealed Guerendo was held out of ...

Guerendo is expected to take over as the 49ers' lead back for the remainder of the regular season after head coach Kyle Shanahan said Monday that both Christian McCaffrey (knee) and Jordan Mason ...

Guerendo (foot) is listed as active Thursday against the Rams, Lindsey Pallares of the 49ers' official site reports. Guerendo came out of this past Sunday's win versus the Bears with a sprained foot, ...

Rookie Isaac Guerendo has been elevated to the 49ers’ starting running back after San Francisco had to put both Christian McCaffrey and backup Jordan Mason on the IR on the same day. The news of ...

A former track standout and converted wide receiver, Guerendo rushed 14 times for 85 yards and a touchdown and added 17 yards on three receptions as San Francisco took care of Dallas. Isaac ...

SANTA CLARA, Calif. -- As the first quarter wound down in his second NFL game, San Francisco 49ers running back Isaac Guerendo trotted on to the field, stepped into the huddle and listened ...

One is on the 53-man roster, and the other is on the practice squad. Guerendo, a fourth-round rookie out of Louisville, is expected to have a chance to operate as San Francisco's lead back with ...

So, while Mason will be the top add in fantasy football this week, managers should also be grabbing Isaac Guerendo. The rookie, I would argue, has looked better than Mason when he’s had a chance ...