San Francisco 49ers rookie running back Isaac Guerendo sustained a foot injury and is questionable to return in Sunday's ...

Here’s one way to view the San Francisco 49ers’ running back situation: They were down to their fourth option Sunday, after injuries sidelined Christian McCaffrey, Jordan Mason and Elijah Mitchell.

SANTA CLARA — When Isaac Guerendo trots onto the field with the ... and it came in his final college game at Louisville. Against USC in the Holiday Bowl, Guerendo carried 23 times for 161 ...

Isaac Guerendo is likely to take the place of Christian McCaffrey ... In the 2023 Holiday Bowl, Guerendo rushed for a season ...

SANTA CLARA — When Isaac Guerendo trots onto the field with the ... and it came in his final college game at Louisville. Against USC in the Holiday Bowl, Guerendo carried 23 times for 161 ...

The 49ers are not expected to have Guerendo (hamstring) available for Sunday's game against the Dolphins, Adam Schefter of ESPN reports.

Guerendo (foot, hamstring) has been ruled out for Sunday's game at Miami, Matt Maiocco of NBC Sports Bay Area reports. Guerendo didn't practice this week and thus appears in danger of missing time ...

The 49ers have gotten used to being shorthanded at running back this season and it looks like they'll be down another one in Miami on Sunday.

Isaac Guerendo is a largely untested talent. He spent five years in college and was mostly unproductive until his final year, where he still failed to surpass 900 rushing yards. Nevertheless ...

The San Francisco 49ers running back Isaac Guerendo is dealing with a hamstring injury and is unlikely to play Sunday at the Miami Dolphins, a source told ESPN's Adam Schefter on Thursday.

Entering a do-or-die matchup vs. the Chicago Bears this Sunday, the San Francisco 49ers are banking on rookie running Isaac Guerendo to fill the shoes left by reigning Offensive Player of the Year ...

SANTA CLARA — The 49ers' NFC matchup with the Chicago Bears on Sunday will be Isaac Guerendo’s chance to shine. The rookie running back has had few chances to show what he is capable of in his ...