San Francisco 49ers rookie RB Isaac Guerendo suffered MCL and ankle sprains against the Arizona Cardinals, avoiding an ACL injury.

The 49ers lost their standout rookie Isaac Guerendo in scary fashion. What update did the running back provide Monday?

San Francisco 49ers running back Isaac Guerendo gave a positive update on his knee injury Monday, noting he did not tear his ACL as some had speculated: ...

GLENDALE -- San Francisco 49ers RB Isaac Guerendo was carted off the field in Week 18's matchup against the Arizona Cardinals. He has already been ruled out with a knee and ankle injury. On just the ...

Guerendo won't return to Sunday's game at Arizona due to knee and ankle injuries. Guerendo had his left leg twisted under him on his second carry of the game, and his teammates quickly motioned to the ...

Guerendo took nine carries for 34 yards while bringing in all four targets for 65 yards in Monday's 40-34 loss to the Lions. Guerendo made a successful return from a one-game layoff due to foot and ...

Also appearing on Wednesday’s injury report was running back Isaac Guerendo after suffering a hamstring injury in last week’s game against the Los Angeles Rams. The rookie played through a ...

San Francisco 49ers running back Isaac Guerendo appeared on Wednesday's injury report due to a hamstring issue sustained during last week's game against the Los Angeles Rams. The rookie had played ...

It appears the 49ers could be without another starting running back for Sunday's game against the Miami Dolphins at Hard Rock Stadium. Rookie running back Isaac Guerendo is dealing with a ...

San Francisco 49ers running back Isaac Guerendo is dealing with a hamstring injury and is unlikely to play Sunday at the Miami Dolphins, a source told ESPN's Adam Schefter on Thursday. Guerendo ...

Yet another San Francisco 49ers running back seems set to miss some action, as ESPN insider Adam Schefter reports “it looks as if” Isaac Guerendo will miss Sunday’s matchup against the Miami ...