Injuries have decimated the reigning NFC champs. Isaac Guerendo, however, provided a promising update. The alternate running back appears to be on his way back, per 49ers reporter Nick Wagoner of ...

Coach Kyle Shanahan said Monday that the 49ers expect Guerendo (foot/hamstring) to practice Thursday, Nick Wagoner of ESPN.com reports. Guerendo picked up foot and hamstring injuries in Week 15 ...

San Francisco 49ers running back Isaac Guerendo. / Bob Kupbens-Imagn Images The San Francisco 49ers are already down Jordan Mason and Christian McCaffrey in their backfield (both are on injured ...

49ers head coach Kyle Shanahan called running back Isaac Guerendo a long shot to play against the Dolphins earlier this week and he moved to no shot on Friday. Guerendo was ruled out for Week 16 when ...

Turner still uses Mostert as a model in film sessions. And his fondness for Mostert was evident when the 49ers drafted Isaac Guerendo, a tailback with plenty of Mostert-like characteristics ...

Also appearing on Wednesday’s injury report was running back Isaac Guerendo after suffering a hamstring injury in last week’s game against the Los Angeles Rams. The rookie played through a ...

It appears the 49ers could be without another starting running back for Sunday's game against the Miami Dolphins at Hard Rock Stadium. Rookie running back Isaac Guerendo is dealing with a ...

San Francisco 49ers running back Isaac Guerendo is dealing with a hamstring injury and is unlikely to play Sunday at the Miami Dolphins, a source told ESPN's Adam Schefter on Thursday. Guerendo ...

San Francisco 49ers running back Isaac Guerendo is unlikely to play in Sunday's game against the host Miami Dolphins, ESPN reported Thursday. Guerendo is nursing a foot injury sustained in the ...

Yet another San Francisco 49ers running back seems set to miss some action, as ESPN insider Adam Schefter reports “it looks as if” Isaac Guerendo will miss Sunday’s matchup against the Miami ...