Isaac Guerendo hasn't started a game at running back since the fourth grade. Now he's the 49ers starting running back for the remainder of the season. Here's the good news for the 49ers ...

Isaac Guerendo is expected to step in as the San Francisco 49ers' starting running back after injuries to Christian McCaffrey and Jordan Mason. Guerendo, a versatile fourth-round rookie from ...

Both players will be placed on Injured Reserve and will be out for the season. That means rookie Isaac Guerendo will be the starter for the remainder of the season. Guerendo has shown flashes this ...

Entering a do-or-die matchup vs. the Chicago Bears this Sunday, the San Francisco 49ers are banking on rookie running Isaac Guerendo to fill the shoes left by reigning Offensive Player of the Year ...

SANTA CLARA, Calif. -- As the first quarter wound down in his second NFL game, San Francisco 49ers running back Isaac Guerendo trotted on to the field, stepped into the huddle and listened ...

The 49ers lost both first-string running back Christian McCaffrey and second-string running back Jordan Mason to injuries last week in Buffalo, leaving only rookie Isaac Guerendo available.

Guerendo is expected to take over as the 49ers' lead back for the remainder of the regular season after head coach Kyle Shanahan said Monday that both Christian McCaffrey (knee) and Jordan Mason ...

Guerendo took four carries for 19 yards and a touchdown while losing three yards on his only reception in Sunday's 35-10 loss to the Bills. Guerendo got some extra run in the second half after ...

Here’s the latest fantasy football news and advice to help you with your lineups this week and moving forward, especially regarding RB Isaac Guerendo. Guerendo is not listed on the injury report ...

SANTA CLARA — When Isaac Guerendo trots onto the field with the first team Sunday at Levi’s Stadium, he will equal the same number of starts he had in five years of college football.