The San Francisco 49ers will reportedly likely be without yet another running back for Sunday's game against the Miami ...

The San Francisco 49ers running back spot has been a position of focus for fantasy football players throughout the season, ...

San Francisco 49ers rookie RB Isaac Guerendo punched in a touchdown in the team's Week 14 matchup against the Chicago Bears.

Los Angeles Rams outside linebacker Byron Young engulfs San Francisco 49ers running back Isaac Guerendo on an authoritative tackle for a loss in the rain.

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

they turned to rookie Isaac Guerendo with some Patrick Taylor Jr. thrown in for good measure and it was one of the highlights of a 38-13 win over the Chicago Bears Sunday at Levi’s Stadium.

they turned to rookie Isaac Guerendo with some Patrick Taylor Jr. thrown in for good measure and it was one of the highlights of a 38-13 win over the Chicago Bears Sunday at Levi’s Stadium.

San Francisco 49ers RB Isaac Guerendo sped past the Buffalo Bills defense for a touchdown on "SNF" San Francisco 49ers RB ...

San Francisco 49ers running back Isaac Guerendo's second touchdown of day gets 49ers to 30-point mark vs. Chicago Bears.

San Francisco 49ers running back Isaac Guerendo turns on the burners with a 30-yard dash.

Los Angeles Rams rookie safety Kam Kinchens makes a touchdown-saving pass break-up on Buffalo Bills quarterback Josh Allen's heave downfield.