San Francisco 49ers rookie running back Isaac Guerendo's 15-yard rushing score ... touchdown from Week 15 of the 2024 NFL Season. Watch highlights from the Week 15 matchup between the Atlanta ...

The San Francisco 49ers will reportedly likely be without yet another running back for Sunday's game against the Miami ...

Los Angeles Rams outside linebacker Byron Young engulfs San Francisco 49ers running back Isaac Guerendo on an authoritative tackle for a loss in the rain.

San Francisco 49ers rookie RB Isaac Guerendo scored a one-yard touchdown in the team's Week 14 matchup against the Chicago Bears.

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

The San Francisco 49ers running back spot has been a position of focus for fantasy football players throughout the season, ...

Isaac Guerendo's status for Thursday's game is "up in the air" after suffering a foot sprain in a win vs. the Bears.

Guerendo managed to play through a foot injury and suit up for last Thursday's 12-6 loss to the Rams, but he's emerged from the contest nursing a new issue. With Christian McCaffrey (knee) and Jordan ...

The 49ers are not expected to have Guerendo (hamstring) available for Sunday's game against the Dolphins, Adam Schefter of ESPN reports.

On "Good Morning Football", NFL Network Insider Mike Garafolo elaborates on the status of San Francisco 49ers running back ...

The San Francisco 49ers running back Isaac Guerendo is dealing with a hamstring injury and is unlikely to play Sunday at the Miami Dolphins, a source told ESPN's Adam Schefter on Thursday.