The most complex engineering of human cell lines ever has been achieved by scientists, revealing that our genomes are more ...

This article explores the transformative potential and challenges of single cell omics in advancing our understanding of ...

This repository provides a comprehensive analysis pipeline designed for the processing and visualization of single-cell RNA sequencing ... is tailored to work with the PBMC 3K dataset, which is a ...

One in every 10 people worldwide is impacted by a rare genetic disease but about 50% of them remain undiagnosed despite rapid ...

Extending Brenner’s work ... the cell lineage of C. elegans, which is the developmental history of all cells of this nematode. He tracked cell divisions from the fertilised single cell to ...

Plasma cells (PCs) are the terminal differentiation stage of activated B cells and serve as crucial effector cells in humoral immunity. While PCs have ...

To understand how tissues work or malfunction ... Visium from 10x Genomics captures information about the expression of all genes in a tissue, but does not provide single-cell resolution.

Methods Single-cell RNA sequencing was performed by droplet-based sequencing (10x Genomics), focusing on 3729 CD3 + lymphocytes ... analysed data and prepared the manuscript. Funding This work was ...

To maintain its effectiveness, the immune system produces highly specialized cell types that work together to prevent ... developmental trajectories for immune cells (4). Single-cell RNA sequencing ...