Nanobody repairs misfolded CFTR inside cells, boosting function in cystic fibrosis

A tiny antibody component could fundamentally transform the treatment of cystic fibrosis: For the first time, researchers ...

How an unsolved medical mystery became a life-saving breakthrough

Inside the deadly disease confounding medicine, researchers piecing together clues and the breakthrough that meant survival ...
Gut

Loss of sinusoidal endothelial identity: RAP1A at the crossroads of capillarisation and liver fibrosis

Liver fibrosis represents a serious worldwide health issue with a prevalence of around 5% in general populations.1 The most ...
AHA/ASA Journals

Targeting Interleukin-8–Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome

BACKGROUND: Genetic variants in components or regulators of the RAS-MAPK signaling pathway are causative for severe and early-onset hypertrophic cardiomyopathy (HCM) in patients with Noonan syndrome ...