How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...

Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme ubiquitously present in all living cells, playing a pivotal ...

Further, Acetyl-CoA, the substrate for the histone acetylation is mainly synthesized by PDC in the nucleus and ACL by using the citrate, a product of TCA cycle in the mitochondria. Therefore, SAM and ...

1,3 In recent years, mitochondrial dysfunction has become a possible mechanism that could explain the development of sarcopenia. Transformations in mitochondria function are seen before the loss ...

Loss of MTCH2 enhances mitochondrial oxidative function. MTCH2 depletion increases energy demand, expenditure and oxidative redox potential. Elevated mitochondrial oxidative function is supported by ...

Mitochondria are vital to energy production ... This enzyme links the two stages of cellular respiration: glycolysis and the citric acid cycle. In doing so, pyruvate dehydrogenase helps regulate ...

Mitochondria are vital to energy production in cells and ... This enzyme links the two stages of cellular respiration: glycolysis and the citric acid cycle. In doing so, pyruvate dehydrogenase helps ...

aCenter for Renal Translational Medicine/Institute for Metabolomic Medicine, University of California San Diego, San Diego, CA, United States bDepartment of Clinical and Molecular Medicine, Faculty of ...

The reaction is often delayed, usually only manifesting with symptoms after two or more days. Sensitivity or intolerance to citric acid found in citrus fruits can also cause allergy-like symptoms. In ...