Asymmetric chromatid segregation is significantly enhanced by Pim-1 overexpression in CPCs (9.19 versus 4.79 in eGFP-expressing cells; P=0.006). Conclusions: Asymmetric segregation of chromatids in ...

"We have obtained a cryo-electron microscopy structure that captures the state of human Rad51 tightly bound to broken DNA," says co-lead author Luay Joudeh, Microscopy Manager at the Departments ...

Directional genomic hybridization (dGH ™) is a cytogenomics-based technology uniquely capable of detecting SVs at high resolution on a cell-by­-cell basis.The technology, which originated at ...

To evaluate the function of cohesin and its regulators, classifications of chromosomes based on the positional relationship between sister chromatids are used. Although the analysis has been done ...

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Scientists from Tokyo Metropolitan University have used machine learning to automate the identification of defects in sister chromatid cohesion. They trained a convolutional neural network (CNN ...

Tokyo, Japan – Scientists from Tokyo Metropolitan University have used machine learning to automate the identification of defects in sister chromatid cohesion. They trained a convolutional neural ...

Tokyo, Japan – Scientists from Tokyo Metropolitan University have used machine learning to automate the identification of defects in sister chromatid cohesion. They trained a convolutional ...

Different experimental approaches, including chromosome conformation capture sequencing (Hi-C) of isolated mitotic chromosomes, polymer modelling, and microscopic observations of sister chromatid ...

Similar trends in the yields of chromatid breaks were also obtained for the 82-6 hTERT cells when the G2-checkpoint was abrogated using VE-821 or UCN-01 ().Specifically, the mean values of chromatid ...

Figure 2 Examples of individual Hordeum vulgare (2n = 14) chromosomes with sister chromatid exchanges (SCEs) in control, MH- and gamma-ray-treated root meristem cells. The EdU-substituted chromatids ...