CRISPR-Cas systems are adaptive immune systems found in prokaryotes that defend against invading nucleic acids through CRISPR ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. During gastrulation, mesodermal cells derived ...

Scientists have uncovered how a key type of immune cell adapts its behavior depending on the type of infection, paving the way for better vaccines and advancing research into immune-related diseases.

Transplanted mouse and human organoids showed kidney-like functions like blood filtration, protein uptake, and urine production.

In a new study conducted at the University of Hawaiʻi at Mānoa, researchers from the John A. Burns School of Medicine (JABSOM) have shown that the loss of a key male fertility gene leads to ...

A study at the University of Hawaiʻi at Mānoa by researchers from the John A. Burns School of Medicine (JABSOM) found that ...

When brain development gets off to a bad start, the consequences are lifelong.   One example is a condition called SCN2A haploinsufficiency, in which children are born with just one functioning copy ...

In a move that could reshape drug discovery, researchers at Harvard Medical School have designed an artificial intelligence model capable of identifying treatments that reverse disease states in cells ...

For families of children with severe epilepsy, controlling seizures is often just the beginning of their challenges. Even in cases where powerful medications can reduce seizures, many children ...

In human cells, there are about 20,000 genes on a two-meter DNA strand—finely coiled up in a nucleus about 10 micrometers in diameter. By comparison, this corresponds to a 40-kilometer thread packed ...

New AI tool accurately identifies multiple drivers of disease in cells and predicts therapies that can restore cells to healthy function. The advance moves away from traditional drug discovery ...