By putting a carbon atom in place of a core oxygen, chemists constructed an opioid that blocks pain with less respiratory ...

Reactions that alter organic scaffolds by a single atom are already proving useful, but time will tell if they’ll ...

This Special Issue is a testament to the dynamic and rapidly evolving field of covalent modulators in medicinal chemistry and drug discovery. The collection of Articles showcases the breadth and depth ...

MDM2, a key negative regulator of the tumor suppressor p53, has emerged as a compelling therapeutic target in human cancer. This Viewpoint summarizes the discovery of a potent and orally bioavailable ...