Two Super Bowl victories and two Super Bowl MVPs, but a .500 record and 244 interceptions. Whatever his legacy is, Manning is ...

The Detroit Lions scored on five consecutive drives in the second half to pull away for a 40-34 win over the host San Francisco 49ers on the final "Monday Night Football" matchup of the season.

Jared Goff and the Detroit Lions visit Levi’s Stadium for the final home game of this injury-riddled 49ers season Click to share on Facebook (Opens in new window) Click to share on Twitter ...

Safety Ji'Ayir Brown had started for the San Francisco 49ers in every game this season. That ended in Week 14 when the 49ers played the Chicago Bears. With Talanoa Hufanga activated off of Injured ...

SANTA CLARA -- The 49ers just lost 40-34 to the Detroit Lions. Here are the 49ers' grades for this emabarrassing performance. Brock Purdy was an extreme version of the quarterback he has been all ...

Either way, we’ll likely hear their names often on Monday Night Football, as one of those newcomers will be protecting 49ers’ quarterback Brock Purdy’s blindside against the Lions.

Brock Purdy threw for a career-high 377 yards and three touchdowns as the San Francisco 49ers fell to the Detroit Lions 40-34 at Levi's Stadium on Monday Night Football. Purdy also threw two ...

The Detroit Lions probably didn’t have to play their starters on Monday night, but did, and the blueprint for the rest of their season became clearer. The Lions can score a lot of points.

Lions 40, 49ers 34, final: The 49ers score a touchdown but can’t recover the onside kick as the Lions hold on for their 14th win of the season. Jared Goff threw for 300 yards, Jahyr Gibbs ran ...

The Detroit Lions will square off with the San Francisco 49ers on Monday Night Football in Week 17 of the NFL season at Levi’s Stadium, scheduled to start at 8:15 p.m. EST. All week, questions ...