The San Francisco 49ers took on the Arizona Cardinals on Sunday at Levi's Stadium. Here's who needs more work for the 49ers after this result.

San Francisco 49ers star edge rusher Nick Bosa suffered a torn ACL on Sunday against the Cardinals that will likely rule him out for the remainder of the season, according to multiple reports. ESPN's Adam Schefter was first to report.

Injuries have accumulated quickly for the 49ers. In addition to Bosa and Purdy, star tight end George Kittle (hamstring), wide receiver Jauan Jennings (shoulder, ankle) and left guard Ben Bartch (ankle) have been hampered by injuries.

San Francisco 49ers defensive tackle CJ West will have thumb surgery after an injury sustained in their victory over the Arizona Cardinals.

SANTA CLARA — The 49ers stand atop the NFC West, but their ability to remain there got a lot more difficult with the new that edge rusher Nick Bosa was lost for the season with a torn ACL.

The change from +390 to +750 translates to a drop from 20.4% to 11.8%. A big chunk of this nearly 9 percentage point drop went to the Chargers who went from under a 7% chance to over a 12% chance based on the odds. The rest was made up by the Bills and Ravens. It would have been even worse for the Chiefs if not for Joe Burrow's injury.

San Francisco 49ers star defensive end Nick Bosa reportedly will undergo season-ending surgery after suffering a torn ACL against the Arizona Cardinals on Sunday, according to ESPN's Adam Schefter.

The 49ers are among six undefeated teams left after three weeks, thanks to a walk-off win over the Arizona Cardinals.

How do all 32 teams in the NFL stack up against each other going into Week 4 of the 2025 NFL regular season? Here's an updated look from best to worst.

San Francisco 49ers kicker Eddy Piñeiro, center, celebrates his game-winning field goal after an NFL football game against the Arizona Cardinals, Sunday, Sept. 21, 2025, in Santa Clara, Calif.