The San Francisco 49ers did little right Sunday, with only the defense showing any signs of life as they fell to the ...

The Jacksonville Jaguars improve to 3-1 on the season with a 26-21 road win over the San Francisco 49ers in Santa Clara.

San Francisco 49ers WR Ricky Pearsall goes for a one-handed catch, hauling in a 31-yard pass from QB Brock Purdy.

San Francisco 49ers QB Brock Purdy slipped a screen to TE Jake Tonges, who takes it 21 yards to the house against the Jaguars.

Trevor Lawrence and the Jacksonville Jaguars are on the west coast this weekend as they prepare to face the San Francisco ...

The 49ers hosted DB Shilo Sanders, brother of Shedeur and son of Deion, this week but did not sign him. More at Pro Football ...

Each week of the NFL season, Yardbarker will be monitoring players who have suffered notable injuries. From a Baltimore ...

Jennings (ankle/shoulder) is active for Sunday's game versus the Jaguars, Briana Jeannel of the 49ers ' official site reports.

Watch highlights from the Week 4 matchup between the Jacksonville Jaguars and the San Francisco 49ers during the 2025 NFL season.

The big game of the late slate was the Kansas City Chiefs hosting the Baltimore Ravens and it ended up in a stroll for ...

Jaguars HC Liam Coen could be seen yelling at 49ers DC Saleh as he was being held back by offensive lineman Robert Hainsey following Jacksonville's 26-21 win over San Francisco on Sunday.

Despite being hit hard by injuries the San Francisco 49ers remain undefeated heading into Week 4. Next up on the schedule ...