Well, this was an interesting game. The Cardinals came up just short in the end on the road against San Francisco. There were some positives. But they were plen

Here are five takeaways from the loss: The Cardinals defense gave the offense every chance. With 3:15 to play, Calais Campbell earned a safety on a holding penalty, putting Arizona up, 15-13. All the offense had to do was pick up a few first downs and run out the clock.

The Arizona Cardinals offense squandered opportunity after opportunity in a 16-15 loss to the San Francisco 49ers. They fell to 2-1 with the defeat.

ARIZONA -- The Arizona Cardinals fell for the first time 2025 following their Week 3 loss to the San Francisco 49ers, dropping their record to 2-1 on the season. While the season is by no means over, conversations around the team have reached a boiling point as their inconsistent offense and inability to close out games finally caught up with them.

The walking-wounded Niners gutted out another victory, this time without their star defensive end, as a host of teammates stepped up.

The San Francisco 49ers lost Nick Bosa to a knee injury in the first quarter, and in the second quarter, they may have lost Mykel Williams.

Take a look at which facets of the Cardinals' performance saw their stocks rise and fall in the heartbreaking defeat in San Francisco.

Bosa appeared to injure his knee late in the first quarter, while Conner left with an ankle injury after a short run in the third.

The next man up on the depth chart is six-year veteran Yetur Gross-Matos, who is playing in his second season with the 49ers. He's a solid option with four sacks in 2024, but a clear step down from Bosa.

Who won the Arizona Cardinals vs San Francisco 49ers game? Check out our updates, highlights and analysis from the NFL Week 3 game.