The San Francisco 49ers return to Levi's Stadium to host the Detroit Lions on ESPN's Monday Night Football. This matchup ...

The San Francisco 49ers released a statement on the passing of Trent Williams’ son. “The 49ers mourn the passing of Trent Williams' son and send him and his family all our love,” the 49ers ...

After games on both Thanksgiving and Black Friday, the NFL caps off the Sunday slate with the Buffalo Bills hosting the San Francisco 49ers. Buffalo's fresh off a bye following a statement win ...

The San Francisco 49ers aim to improve their 5-7 record in Week 14 when they take on the Chicago Bears. However, injury woes have plagued the roster, with the regular season approaching an end.

San Francisco 49ers player Trent Williams and his wife Sondra are mourning the passing of their newborn son, the couple revealed on Monday. "It's been extremely hard trying to process the saddest ...

49ers left tackle Trent Williams’ wife Sondra announced the tragic death of their newborn son, Trent Jr. In a post on Instagram on Sunday, Sondra revealed that she lost Trent Jr.’s twin early ...

Orchard Park, N.Y. — The Buffalo Bills dominated the San Francisco 49ers on a snowy night at Highmark Stadium, winning 35-10 and clinching the AFC East title for the fifth consecutive season.

and past the 49ers, 35-10, in a game that saw and Josh ... youngsters Nakobe Dean and Reed Blankenship have made the leap, and free agent addition Zack Baun is a star. Credit Howie Roseman ...

The San Francisco 49ers are in dire straights after a blowout loss to the Buffalo Bills, and QB Brock Purdy knows it. San Francisco dropped to 5-7 after a 35-10 defeat in Buffalo. After the major ...

Check out these NFL Week 14 picks and NFL Week 14 predictions for the game, which can be seen at 2:25 p.m. MST on FOX (stream with free trial from FUBO). The 49ers are a 4-point favorite over ...

That’s what kind of night it was for the Bills as they crushed the overmatched and out-of-their-element San Francisco 49ers 35-10 in a snow globe game to clinch their fifth consecutive AFC East ...

San Francisco 49ers quarterback Brock Purdy will start Sunday night against the Buffalo Bills. Purdy was originally listed as questionable due to his right shoulder injury but didn't experience ...