Buffalo Bills safeties Damar Hamlin and Taylor Rapp, who were questionable for the road game against the Detroit Lions, were on the inactive list Sunday.

Here are three causes for concern for the Bills against the Patriots in Week 16: What would make Patriots rookie quarterback Drake Maye’s day a bit easier on Sunday would be if the Bills are down members of their secondary. Safeties Damar Hamlin and Taylor Rapp, along with cornerback Rasul Douglas, all missed Week 15’s win over the Detroit Lions.

Rapp missed his second game of the season in Buffalo's win this past weekend against Detroit, and he's now at risk of missing back-to-back matchups. The veteran is joined by safety Damar Hamlin on the questionable list, which could prime Kareem Jackson and Cole Bishop for more playing time like last week.

A key cornerback will not play against the Lions, and two other defenders are questionable. Here's the Bills' injury update.

Buffalo Bills head coach Sean McDermott announced on Friday that starting cornerback Rasul Douglas will miss the Week 15 game at the Detroit Lions due to his knee injury suffered in the loss to the LA Rams last week.

The Buffalo Bills are monitoring injuries to their starting safety and boundary cornerback heading toward a Week 15 matchup against the Detroit Lions.

Sean McDermott did not rule anyone out for Sunday, but six defensive players, including four starters, will be questionable.

The New England Patriots are hitting the road this weekend to take on the Buffalo Bills on Sunday afternoon for a Week 16 battle. These two teams will also meet in Week 18, and with the Bills still fighting for the top seed in the AFC,

Buffalo Bills cornerback Rasul Douglas gave up a touchdown and suffered a back injury on the same play against the Los Angeles Rams on Sunday. Douglas collided with safety Taylor Rapp while trying ...

After signing to the Buffalo Bills' practice squad earlier this month, Micah Hyde may soon see live game action.

Listed as questionable are receiver Curtis Samuel (rib), cornerback Rasul Douglas (knee), linebackers Matt Milano (biceps/groin), Dorian Williams (elbow) and Baylon Spector (calf) and safeties Taylor Rapp (neck) and Damar Hamlin (rib). All were limited practice participants on Friday.

The Bills gave up 521 yards playing without starting safeties Taylor Rapp (neck/shoulder) and Damar Hamlin (ribs), and starting cornerback Rasul Douglas (knee). Buffalo limped along by activating defensive end Dawuane Smoot and linebacker Baylon Spector from injured reserve and elevating safety Kareem Jackson from the practice squad.