A 31-year-old man was evaluated for an abnormal ECG. Echocardiography revealed marked ventricular hypertrophy. Subsequent ...

Once-daily, single-tablet regimens have transformed care for persons living with human immunodeficiency virus type 1 (HIV-1); ...

Big data, we have all heard, promise to transform health care. But in the “hype cycle” of emerging technologies, machine learning now rides atop the “peak of inflated expectations,” and we need to ...

Personalized therapies hold tremendous promise but challenge traditional models of drug and biologic development. The FDA outlines a path to market entry for products where a randomized trial is no ...

How can we change a system, and a culture, in which suicide can look to physicians like an attractive escape from the relentless demands of medical practice?

Health worker burnout, exacerbated by Covid-19, is not only about long hours. It’s about the fundamental disconnect between health workers and the mission to serve that motivates them.

When a patient receives a diagnosis of amyotrophic lateral sclerosis, he is shocked. But he’s also dubious enough to seek a second opinion.

Explore this issue of The New England Journal of Medicine (Vol. 395 No. 4).

In 832 patients with rare genetic disease, a conclusive diagnosis was made for 160 patients (19.2%) with long-read genome sequencing and for 137 patients (16.5%) with standard-of-care testing.

This study supports enzymatic cross-correction of neurons and oligodendrocytes by atidarsagene autotemcel, a gene therapy ...

Explore this issue of The New England Journal of Medicine (Vol. 394 No. 10).

Supported by a grant (TTU 08.711, to Christoph M. Ernst) from the German Center for Infection Research (DZIF), by a gift from A. and J. Bekenstein (to Deborah T. Hung), and by a grant (U19AI110818, to ...