Objectives CD163 is a macrophage-associated scavenger receptor shed during inflammatory activation, resulting in measurable ...

Objectives To estimate the risk of venous thromboembolism (VTE) in a nationwide cohort of newly diagnosed patients with SLE ...

Objective Belimumab has been proven to be effective for treating refractory lupus nephritis. However, the meaningful renal ...

Objective Childhood-onset SLE (cSLE) is often described as more severe than adult-onset disease (aSLE) based largely on cross ...

Objective We aim to assess the cerebral oxygen extraction fraction (OEF) changes in patients with systemic lupus erythematosus (SLE) and neuropsychiatric SLE (NPSLE) by using an MRI-based technique ...

Background Cognitive dysfunction (CD) is highly prevalent in systemic lupus erythematosus (SLE), yet the underlying mechanisms are poorly understood. Neuroimaging utilising advanced MRI metrics may ...

Objectives Systemic lupus erythematosus (SLE) is a systemic autoimmune disease in which hypertension and cardiovascular disease are prevalent; yet the underlying mechanisms are not fully understood.

Objective Combination therapy with rituximab and belimumab is a novel treatment strategy for severe SLE and lupus nephritis. Phase II studies have shown promising results, although long-term data are ...

Objective Two recent important lupus nephritis trials reported that proteinuria was a good predictor of renal outcome in Caucasians, but data on real-life situation, other races and severe nephritis ...

Objectives In Breakfree-1 (NCT05869955), BMS-986353 (CD19 NEX-T®), a CD19-directed CAR T cell therapy, showed promising early safety and efficacy in severe, refractory SLE. We report updated data for ...

Objective Autoimmune haemolytic anaemia (AIHA) occurs in approximately 5–10% of patients with SLE and it is traditionally associated with higher disease activity, increased damage accrual and reduced ...

Objective Complement plays a major role in SLE. Complement participation has been linked to disease activity and damage. Our objective was to estimate the association of complement behaviour with ...