Understanding the risks associated with healthcare interventions is essential for clinical decision-making and for the ...

Target Trial Emulation (TTE), a framework for improving observational research, is attracting attention and increasingly ...

Background The adaptation of clinical practice guidelines (CPGs) is increasingly used to efficiently develop contextualised recommendations for local, regional and national settings. However, ...

Several organisations, such as the WHO, have endorsed network meta-analysis (NMA) as a powerful tool in clinical decision making. NMA is a statistical method, which simultaneously compares multiple ...

Introduction In 2013, the Observing Patient Involvement in Decision Making instrument (OPTION-5) was developed to measure levels of shared decision-making (SDM) in consultations. 1 Since then, it has ...

Less is more for patients, practitioners, public and planet: a taxonomy for the harms of too much medicine ...

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Correspondence to Dr Mohammad H Murad, Evidence-based Practice Center, Mayo Clinic, Rochester, MN 55905, USA; murad.mohammad{at}mayo.edu Many guidelines use the term expert opinion in recommendations ...

Correspondence to Professor Kari A O Tikkinen, Department of Urology, Helsinki University Hospital, Helsinki 00290, Finland; kari.tikkinen{at}helsinki.fi To practice high quality healthcare, ...

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Associate Editor, Evidence Based Medicine, Department of Family Medicine, University of Alberta, Canada Correspondence to Denise Campbell-Scherer Associate Professor, Department of Family Medicine, ...

1 Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, UK, Oxford, UK 2 Basel Institute for Clinical Epidemiology ...