Scientists have uncovered a surprising mechanism by which a brain enzyme called OTULIN controls the expression of tau, the ...

Researchers found that tau proteins don’t jump straight into forming Alzheimer’s-associated fibrils—first they assemble into ...

New research has shown that the enzyme OTULIN regulates tau at the gene-expression level rather than through protein ...

Researchers found that melting soft tau protein precursors before they form harmful fibrils could shift Alzheimer's treatment ...

Johnson & Johnson’s attempt to develop a $5 billion-a-year Alzheimer’s disease drug has been rocked by a phase 2 flop. | Johnson & Johnson’s attempt to develop a $5 billion-a-year Alzheimer’s disease ...

More than a century ago, Alois Alzheimer noted unusual changes in brain fats, which he described as "lipoid granules," along ...

Researchers discovered a connection between Alzheimer’s disease, tau proteins, and the herpes HSV-1 virus that is responsible ...

Alzheimer’s disease has long been defined by what the brain loses: neurons, memories, independence. A new wave of research is ...

Newly reported research headed by a team at the Perelman School of Medicine at the University of Pennsylvania points to a potential gene therapy approach to neurodegenerative disorders characterized ...

A promising Alzheimer’s treatment failed to slow the progress of the disease, news that could dampen enthusiasm for a new class of potential medicines.

The lab, led by Carleara Weiss, explores the relationship between Alzheimer’s disease and biomarkers of neurodegeneration, ...