A 60-year-old man presented with a 1-month history of postprandial epigastric pain. CT of the abdomen showed a diffusely enlarged pancreas with a capsule-like rim. Serum levels of IgG4 were elevated.

A 31-year-old man was evaluated for an abnormal ECG. Echocardiography revealed marked ventricular hypertrophy. Subsequent ...

Once-daily, single-tablet regimens have transformed care for persons living with human immunodeficiency virus type 1 (HIV-1); ...

In this phase 3b, open-label, controlled trial, adult participants with obesity but without type 2 diabetes were randomly assigned in a 1:1 ratio to receive the maximum tolerated dose of tirzepatide ...

As legislative support for medical aid in dying grows, the paradox at the heart of this option, with its broader-than-expected benefits, becomes increasingly clear: its expansion hinges on its rarity.

Andes virus (ANDV) is the sole orthohantavirus with documented human-to-human transmission. We summarize the epidemiology and clinical features of ANDV infection and review best practices in clinical ...

How can we change a system, and a culture, in which suicide can look to physicians like an attractive escape from the relentless demands of medical practice?

Explore the current issue of The New England Journal of Medicine (Vol. 395 No. 5).

When a patient receives a diagnosis of amyotrophic lateral sclerosis, he is shocked. But he’s also dubious enough to seek a second opinion.

A 51-year-old woman with right heart failure presented with worsening abdominal distention and leg swelling. Examination was notable for ascites, leg edema, a grade 4/6 holosystolic murmur, and a ...

Explore this issue of The New England Journal of Medicine (Vol. 392 No. 5).

Explore this issue of The New England Journal of Medicine (Vol. 392 No. 3).