NFL picks, predictions, DFS advice and fantasy football rankings from SportsLine's model and team of Vegas experts

This article was originally published on fansided.com as NFL Week 15 picks and predictions, straight-up and ATS: Bills-Patriots, Packers-Broncos lead huge slate.

There are some juicy matchups this weekend, many with playoff implications for the league's top teams. But no one is more desperate than Kansas City.

The Colts have slim playoff hopes, while the Jaguars are trying to win the division. Motivation goes to the Jaguars. The Colts have a ton of major injuries and the defense is a mess. The Jacksonville offense is rolling and Trevor Lawrence will continue that here.

A look at the New York Giants' 53-man roster by jersey number ahead of their Week 17 game vs. the Las Vegas Raiders.

Raiders 6-9. Series record: Raiders lead 9-6. Last meeting: Raiders beat Giants 30-6 on Nov. 5, 2023, at Las Vegas. Last week: Giants lost to the Vikings 16-13; Raiders lost to the Texans 23-21. Giants offense: overall (17),

In a matchup between the NFL's only two-win teams this season, the loser of the New York Giants - Las Vegas Raiders game will control its own destiny to get the No. 1 overall pick in the 2026 NFL Draft entering Week 18.