(HealthDay News) – Treatment with a thiazolidinedione is associated with an increased one- and 10-year risk of diabetic macular edema (DME) in patients with type 2 diabetes, according to a study ...

Compared with nonuse, GLP-1RA and thiazolidinedione combination therapy reduced risks for all-cause and cardiovascular mortality in type 2 diabetes. The combination of a glucagon-like peptide 1 ...

March 25, 2011 — Pioglitazone therapy led to a 72% reduction in the conversion rate from impaired glucose tolerance to type 2 diabetes mellitus, but adverse effects included weight gain and edema, ...

Combination therapy with GLP-1 RA and thiazolidinedione significantly reduces all-cause mortality and cardiovascular mortality in type 2 diabetes patients. The study found an increased risk of ...

CHICAGO – Treatment with glucose-lowering thiazolidinedione drugs in patients with Type 2 diabetes appears to be associated with an increased risk of diabetic macular edema (a complication that may ...

Recent literature suggests that thiazolidinedione use may be related to bone loss, especially in older women with diabetes. 18,19 Pioglitazone therapy may reduce the production of osteoblasts, which ...

May 1, 2008 – Further evidence that long-term use of the thiazolidinediones rosiglitazone and pioglitazone may increase risk of fractures (particularly of the hip and wrist) has come from a new ...

In their recent meta-analysis, Loke and colleagues provided evidence that long-term use of thiazolidinediones is associated with a higher risk of fractures among women but not men.1 Potentially ...

To study whether T33, a new synthesized non-thiazolidinedione (TZD) peroxisome proliferator-activated receptor (PPAR) γ/α dual agonist has an antidiabetic effect on ob/ob mice. Ob/ob mice were treated ...

During fasting periods, hepatic glucose production is enhanced by glucagon to provide fuels for other organs. This process is mediated via cAMP-dependent induction of the CREB regulated ...

According to a report published Online First by Archives of Internal Medicine, a JAMA Network publication treatment with glucose-lowering thiazolidinedione drugs in patients with Type 2 diabetes ...