After spending years tracing the origin and migration pattern of an unusual type of immune cell in mice, researchers headed by a team at The Ohio State University College of Medicine have shown how ...

Rheumatoid arthritis (RA) is an autoimmune disease that affects millions worldwide and can have a devastating impact on patients' lives. Yet, about one in three patients respond poorly to existing ...

For decades, the standard explanation for autoimmune diseases like rheumatoid arthritis has rested on two pillars: inherited ...

After spending years tracing the origin and migration pattern of an unusual type of immune cell in mice, researchers have shown in a new study how activity of "good" microbes in the gut is linked to ...

CHICAGO -- An investigational monoclonal antibody drug targeting the PD-1 ligand on T cells was a winner in a phase II rheumatoid arthritis (RA) trial. Twelve weeks of treatment with the agent, called ...

Although the precise pathogenesis of rheumatoid arthritis remains unclear, it has been postulated that multiple exogenous or endogenous antigenic triggers, or both, act in the presence of a background ...

1 For example, indicators of RA include the presence of rheumatoid factor (RF) and antibodies against citrullinated peptides (anti-CCP), which point toward a central role of activated B cells and ...

Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects the joints. Specifically, the immune system is attacking the body’s own tissues thinking they are pathogenic or deleterious. It ...