The GTPase switch is a versatile molecular device used by many proteins, such as the small GTPases, to regulate an astounding number of functions. Although the basics of the guanine nucleotide cycle ...

Epigenetic mechanisms regulate genome activation in diverse events, including normal development and cancerous transformation. Centromeres are epigenetically designated chromosomal regions that ...

This article and associated images are based on a poster originally authored by Oliver Carney, Louis Hodgson, and Carl Peters, and presented at ELRIG Drug Discovery 2025 in affiliation with BMG ...

Scientists at the University of California, San Francisco (UCSF), have discovered how to target a class of molecular switches called GTPases that are involved in a myriad of diseases—from Parkinson’s ...

Mechanosensitive recruitment of DLC1 to focal adhesions creates a positive feedback loop that locally amplifies Rho activation in response to tension.