Activating the GPR133 receptor with a small molecule can rebuild bone from within, offering a new direction for osteoporosis ...
Signal transduction is the fundamental process by which cells convert external cues into tailored intracellular responses. Through a cascade of molecular events—beginning at the cell membrane with the ...
Blocking the PD-1 signal transduction by occupying the phosphorylated ITSM recognition site of SHP-2
In recent years, immune checkpoint therapy headed by programmed death receptor 1 (PD-1) and programmed death receptor-ligand 1 (PD-L1) has been proven to be safe and effective. However, clinical ...
Novel trial designs like basket, umbrella, and platform trials enhance efficiency and reduce development timelines in precision medicine. Basket trials test a single therapy across different tumor ...
An international team of scientists has developed specialized nanoparticles that can reverse the cognitive symptoms of Alzheimer’s disease in mice. The treatment works by repairing the brain’s natural ...
A quiet shift in dementia science is gathering pace, with lab results hinting at a fresh route to protect fading memories. A team working across China and ...
Scientists have developed an innovative nanotechnology treatment that reverses Alzheimer's disease in mice by restoring the brain’s blood-brain barrier (BBB), a critical vascular ...
SAN FRANCISCO and PORTLAND, Ore. and BOSTON, Nov. 5, 2025 /PRNewswire/ -- Drug Hunter, the leading knowledge platform for ...
This paper describes the isolation, cloning, and molecular characterization of a receptor molecule for calcium ions located on the outer surface of certain types of cells. The reason it has received ...
Edited by: James Kling P.A. Hoodless, T. Haerry, S. Abdollah, M. Stapleton, M.B. O'Connor, L. Attisano, J.L. Wrana, "MADR1, a MAD-related protein that functions in ...
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