A riboswitch can adopt different secondary structures to effect gene regulation depending on whether ligand is bound. This schematic is an example of a riboswitch that controls transcription. When ...

(Phys.org)—A team of researchers working for pharmaceutical company Merck has found an instance of a molecule that is able to flip a switch in a bacterium that prevents it from synthesizing a needed ...

In a discovery that points to potential new antibiotic medicines, scientists from Rice University and the University of Michigan have deciphered the workings of a common but little-understood ...

To prevent a global health crisis, scientists around the world are searching for ways to fight bacteria that can evade the current arsenal of antibiotics. A promising target for new and improved ...

Purine riboswitches have served as models for riboswitch structure, dynamics, evolution and engineering. New crystallographic models reveal the adaptability of a purine riboswitch evolved to bind ...

To prevent a global health crisis, scientists around the world are searching for ways to fight bacteria that can evade the current arsenal of antibiotics. A promising target for new and improved ...

A research team at Merck (accidentally) uncovered a new antibacterial target - a riboswitch important for riboflavin (vitamin B2) biosynthesis. The team screened nearly 60,000 small molecules for ...

Researchers have developed a synthetic small molecule that binds to a bacterial riboswitch to control gene expression. Bacterial riboswitches are add-on segments attached to some of the microbes’ ...

RNA self-regulation is as complex and sophisticated as protein-based gene regulation, according to a report in Science this week. A novel Bacillus subtilis riboswitch as described by the authors is an ...

Researchers have built a synthetic-cell platform that can be chemically adjusted in real time, sidestepping a long-standing bottleneck in artificial cell design. The system, based on coacervate ...

In a discovery that points to potential new antibiotic medicines, scientists have deciphered the workings of a common but little-understood bacterial switch that cuts off protein production. In a ...

In work with implications for functional studies and drug discovery, researchers have identified aptamer ligands (short folded RNAs) capable of distinguishing between on and off states of messenger ...