Proliferating cells, in particular tumor cells, express a dimeric isoenzyme of pyruvate kinase, termed Tumor M2 pyruvate kinase. In the last few years, much attention has been paid to this novel tumor ...

Non-small-cell lung cancer (NSCLC) accounts for up to 85% of all cases of lung cancer, which is the most frequent cause of cancer-related deaths worldwide. The need for effective treatments against ...

Tumor M2-PK is becoming established as a good noninvasive screening option for colorectal cancer with a reported sensitivity between 68.8 and 91.0% and an overall specificity ranging from 71.9 to 100% ...