We previously reported on the partial prevention of experimental shunt-induced pulmonary arterial hypertension (PAH) by the nonselective endothelin (ET) ET-A/ET-B receptor antagonist bosentan. As the ...

High-volume systemic-to-pulmonary ductal shunting occurs frequently in preterm infants and is indicated by diastolic flow reversal in the descending aorta (DAo). We studied the relationship between ...

Systemic to pulmonary arterial shunts are surgically created connections between the aorta and a pulmonary artery in children with cyanotic congenital heart disease, such as tetralogy of Fallot or ...

French intensivists traced a patient's posture-dependent oxygen collapse and multiple strokes to a nineteen-centimetre liver ...

Among patients with advanced chronic obstructive pulmonary disease (COPD), an arteriovenous (AV) shunt improves physiological parameters such as cardiac output and oxygen delivery but does not have a ...

A new physiological review in Intensive Care Medicine explains why shunt drives hypoxaemia, dead space drives carbon dioxide ...

VENOUS anastomoses connecting the portal and pulmonary veins have been shown in cirrhotic patients by post-mortem injection, 1 and there has been considerable speculation concerning their possible ...

Sildenafil (Viagra) is a phosphodiesterase-5 inhibitor currently used for treating erectile dysfunction. Part of its mechanism is the inhibition of cyclic guanosine mono-phosphate (cGMP) metabolism.

A patent foramen ovale has been observed in about 20 per cent of persons surveyed. 5 A similar proportion has been observed in this . . . From the Department of Medicine, Royal Hospital, Sheffield ...