Overview of protein engineering strategies. Directed evolution mimics natural selection in the laboratory through iterative rounds of mutagenesis and screening. Rational design uses structural and ...

Protein engineering holds substantial promise for designing proteins with customized functions, yet the vast landscape of potential mutations versus limited laboratory capacity constrains the ...

Structural biology is entering a new phase beyond the original breakthrough of AlphaFold 2, with two emerging frontiers poised to redefine the field: the prediction of full protein conformational ...

Two projects at the University of California, Davis, that use artificial intelligence to design and engineer proteins for industrial and health applications have been funded by the U.S. National ...