The observations leading to the original formulation of the operon model are discussed. Since then the model has been tested and refined by a variety of methods, both genetical and biochemical, ...

A classic example of negative repressible regulation of gene expression involves the trp operon, which is regulated by a negative feedback loop.

This article aims to describe the regulatory mechanisms that control gene expression in both eukaryotes and prokaryotes.

This simple organization provides an efficient mechanism to coordinate the expression of neighboring genes and is at the basis of gene regulation in bacteria. Here, we report the existence of a higher ...