Memantine blocks some NMDA receptors when they're too active. The combination of memantine and a cholinesterase inhibitor leads to modest improvements in cognition and global outcomes in patients ...

August 24, 2010 — The adamantine derivative, memantine, preferentially blocks excessive extrasynaptic activity of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors (NMDAR), while ...

A class of inhibitors of the NMDA receptor under the generic name Memantine has been approved by the U.S. Food and Drug Administration for use in moderate and severe cases of Alzheimer's.

The results show a distinct distribution of NMDA receptors in the cortex of patients with Alzheimer's disease, ... as memantine, one of the most commonly used drugs for the disease, ...

Brain scan-ss-563672869 Before study initiation, NSE levels were similar for both groups. On Day 3 of the study, the NSE levels were 7.95 ± 2.86 ng/mL for the memantine group and 12.33 ± 7.09 ng ...

Memantine, an NMDA receptor antagonist, is one of only four drugs approved for AD. “The NMDA receptor is so important for disease, and there has been an enormous effort to design different compounds ...

Memantine belongs to a class of drugs called NMDA receptor antagonists. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

"Most NMDA receptors are found in synapses, where they enhance neuronal connections. However, ... as memantine, one of the most commonly used drugs for the disease, ...

Memantine, an NMDA glutamate receptor antagonist, has been the most prominent neuroprotective agent in glaucoma. It was the first drug approved for use as a neuroprotective agent in moderate-to ...

Innovative protocol maps NMDA receptors in Alzheimer's-Affected brains. Universidad Miguel Hernandez de Elche. Funder Fondo de Investigaciones Sanitarias, Direcció General de Ciència i ...

Having noted that overactivated NMDA glutamate receptors cause repetitive behaviors, the research team administered a drug called memantine, a commercially available treatment for Alzheimer's ...