Memantine is an uncompetitive N-methyl-D-aspartate receptor antagonist that blocks pathological glutamate activity while permitting normal physiological function, thus preventing glutamate-induced ...

emphasizes the importance of this type of research due to the role of NMDA receptors in current Alzheimer's treatments, as memantine, one of the most commonly used drugs for the disease ...

Memantine HCl 7mg, 14mg ... see full labeling. Caution with other NMDA antagonists (eg, amantadine, ketamine, dextromethorphan). May affect or be affected by renally-excreted drugs (eg ...

Memantine works by regulating the neurotransmitter glutamate, which activates NMDA receptors on nerve cells. Excess glutamate production can lead to brain cell death, so by inhibiting glutamate ...

Consequently, combination therapy currently involves the administration of one cholinergic drug (donepezil, galantamine or rivastigmine) and one glutamatergic drug (memantine). There have been no ...

the blocking mechanisms of [ketamine and memantine] versus EVT 101 are somewhat different; so the important issue could be achieving a partial block of the NMDA receptors, rather than which ...

This work shows that enhancing the function of the GluN2b subunit of the N-methyl-D-aspartate (NMDA) receptor signaling pathway can correct key neural dysfunctions in a mouse model of fragile X ...