Excessive glutamate receptor activity, principally of theN-methyl-D-aspartate (NMDA) subtype, contributes to neuronal damage in a large number of neurologic disorders, including dementia. Until ...

But doctors do use one NMDA receptor antagonist: memantine (Namenda XR). It's been approved in the U.S. and Europe as a treatment for Alzheimer's disease.

Memantine, an uncompetitive NMDA-receptor antagonist, could be of therapeutic value in Alzheimer's disease. 12 A recent study in patients with advanced dementia (Alzheimer's disease and vascular ...

In this study, recently published in Alzheimer's & Dementia, the authors investigated NMDA (N-methyl-D-aspartate receptors) receptors due to their importance in synaptic transmission and their ...

August 24, 2010 — The adamantine derivative, memantine, preferentially blocks excessive extrasynaptic activity of the N -methyl-D-aspartate (NMDA) subtype of glutamate receptors (NMDAR), while ...

Memantine is a non-competitive glutamate N-methyl-d-aspartate (NMDA) receptor antagonist, approved by the U.S. Food and Drug Administration (FDA) for treatment of Alzheimer’s disease and ...

Memantine is a prescription oral tablet used to treat dementia caused by Alzheimer’s disease. Learn about side effects, warnings, dosage, and more.

Unravelling the minute details of this receptor will help researchers understand its complex function and how it might be better targeted by therapies, wrote the authors. Memantine, an NMDA receptor ...

Memantine is postulated to exert its therapeutic effect through its action as a low to moderate affinity uncompetitive (open-channel) N-methyl D-aspartate (NMDA) receptor antagonist which binds ...

Although similar alterations in NMDA receptors were detected, the differences between species underscore the need for studies on human tissue to better understand the disease.

This process largely depends on synapses, where NMDA receptors play a critical role in learning and memory. “Most NMDA receptors are found in synapses, where they enhance neuronal connections.