The contraction of smooth muscle is an essential process underpinning diverse physiological functions ranging from gastrointestinal motility to vascular regulation. At its core, smooth muscle ...

For most of his career, Richard Lieber ’78, Ph.D. ’83, has focused on understanding and solving painful and debilitating muscle contractures that are the result of cerebral palsy, stroke and spinal ...

When children experience brachial plexus injury at birth, or are born with cerebral palsy, some of the most disabling problems that follow are muscle contractures, or tightness of muscles, that ...

In cerebral palsy (CP), the spastic motor type is most common, associated with a velocity-dependent increase in muscle stiffness that precedes the development of fixed muscle contracture. In ...

In mice, the drug bortezomib preserved muscle growth and prevented loss of elbow and shoulder motion in conditions resembling cerebral palsy and newborn brachial plexus injury, the most common causes ...

Clonus is a neurological condition that creates involuntary muscle contractions. This results in uncontrollable, rhythmic, shaking movements. It’s usually brought on by excessive muscle stretching.

S5 mutations disrupt RyR1 channel function, influencing both channel activity and gating mechanisms. This impacts the release of calcium and affects muscle contractions, leading to severe muscle ...

Traditional lifting often fails as we age; discover the "continuous tension" method that firms skin and muscle without the ...