Maintaining cellular order is a major logistical challenge: Individual mammalian cells contain billions of protein molecules, ...

E3 ligases are enzymes that act as molecular "broker" by binding specific target proteins and coordinating the transfer of ubiquitin from an E2 enzyme. As an E3 ligase recognizes only a restricted set ...

A new study uncovers the intricate molecular mechanisms that regulate leaf senescence in apple plants, focusing on the crucial role of the E3 ligase enzyme, MdPUB23, and its interaction with the ABI5 ...

Traditional drug research has focused on creating inhibitors that occupy the active areas of disease-related proteins, preventing them from functioning properly. But this strategy leaves a ...

Maintaining cellular order is a major logistical challenge: Individual mammalian cells contain billions of protein molecules, which must be synthesized, deployed, and removed with precision.