Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and disease progression. In gynecological malignancies-including ovarian, cervical, and ...

Lactate has emerged from its classical designation as a metabolic by-product to a pivotal signalling mediator that shapes the immune microenvironment. Generated by glycolytic pathways in both tumours ...

D-lactate is the stereoisomer of L-lactate that arises primarily through microbial fermentation in the gut and via the glyoxalase pathway in human tissues. Under normal circumstances, low levels of ...

Elevated levels of lactate may lead to the development of cachexia (disease-related weight loss) following the onset of cancer, according to a study including data from mice and humans published in ...

Lactic acid (LA) has transitioned from being perceived as a mere glycolytic waste product to a pivotal regulator of tumor-immune crosstalk. Historical milestones—from Scheele's 1780 isolation from ...

Pogačar is one of the first to access lactate gels and drinks that could blow up pro cycling. But their performance impact ...

Scientists from Academia Sinica and National Taiwan University, together with international collaborators, have developed a high-performance red fluorescent biosensor for lactate (lactic acid). The ...

A research team led by Prof. Chen Yan and Prof. Yang Lifeng from the Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences revealed a physiological function of monocarboxylate ...

Metabolic reprogramming in fibrotic lung diseases involves key metabolites like lactate, succinate, and 2-hydroxyglutarate, driving inflammation and fibroblast activation. Lactate accumulation ...

People often discuss the importance of removing, or “flushing out,” lactic acid from the blood after intense exercise to reduce muscle soreness, speed recovery, or boost athletic performance. After ...