The intricate regulation of receptor tyrosine kinases (RTKs) underpins a vast array of cellular responses that are essential for growth, differentiation and survival. In particular, the interplay ...

The enzyme RNA polymerase II transcribes genes into messenger RNA. This process is guided by modifications to the enzyme's "tail" called phosphorylation patterns. Scientists at St. Jude Children's ...

Researchers from the Icahn School of Medicine at Mount Sinai have introduced KiNet, an interactive web portal designed to explore kinase-substrate interactions in human cellular systems. These ...

In the human body, molecules known as kinases propagate signals within and between cells, relaying signals that allow cells to respond to changes in the environment. But there are hundreds of ...

When 200 natural accessions of the model plant Arabidopsis thaliana grown in a nitrate-enriched medium were compared, one observation stood out: some ...

A new study reveals that the twin enzymes MNK1 and MNK2 play distinct roles in the brain, with one governing memory and the other social behavior.

Fibroblast growth factor receptor 2 (FGFR2) is a transmembrane tyrosine kinase that regulates signaling pathways controlling cell survival and proliferation. Dysregulation of FGFR2, through ...

Hyperactive signaling pathways of some aggressive blood cancer cells can be tamped down by a previously unrecognized protein complex, ensuring the cancer's survival. If one component of the complex is ...