Should I start or sit Isaac Guerendo for fantasy football in Week 17? Read our fantasy football start 'em, sit 'em picks and ...

The 49ers have been without Isaac Guerendo for most of December. But the RB helped provide a promising update Thursday.

That was until Isaac Guerendo showed up. The rookie fourth-round pick in 2024 stepped into action on Sunday in Week 14, dominating the Bears to the tune of 128 total yards and two touchdowns.

As the 49ers look to play spoiler against the Lions on Monday Night Football, RB Isaac Guerendo got a positive injury update.

Now, rookie Isaac Guerendo finds himself in a spot to lead ... in one of the best combines in the event's history. With a 9.88 RAS, Establish the Run’s Adam Levitan also pointed out that ...

Entering a do-or-die matchup vs. the Chicago Bears this Sunday, the San Francisco 49ers are banking on rookie running Isaac Guerendo to fill the shoes left by reigning Offensive Player of the Year ...

Things only worsened during the win against the Chicago Bears. Fourth-string running back Isaac Guerendo, who drew the start in the absence of his aforementioned teammates, exited the game during ...

San Francisco 49ers rookie running back Isaac Guerendo sustained a foot injury and was questionable to return in Sunday's matchup with the Chicago Bears. More News: Chargers Make Game-Time ...

The San Francisco 49ers got a great performance out of rookie running back Isaac Guerendo in his first career NFL start in Week 14 against the Chicago Bears. However, the fourth-round rookie ...

Yet another San Francisco 49ers running back seems set to miss some action, as ESPN insider Adam Schefter reports “it looks as if” Isaac Guerendo will miss Sunday’s matchup against the Miami ...

San Francisco 49ers running back Isaac Guerendo's second touchdown of day gets 49ers to 30-point mark vs. Chicago Bears. Best catches from San Francisco 49ers tight end George Kittle's 112-yard ...