Entering a do-or-die matchup vs. the Chicago Bears this Sunday, the San Francisco 49ers are banking on rookie running Isaac Guerendo to fill the shoes left by reigning Offensive Player of the Year ...

A former track standout and converted wide receiver, Guerendo rushed 14 times for 85 yards and a touchdown and added 17 yards on three receptions as San Francisco took care of Dallas. Isaac ...

SANTA CLARA — The 49ers' NFC matchup with the Chicago Bears on Sunday will be Isaac Guerendo’s chance to shine. The rookie running back has had few chances to show what he is capable of in his ...

Since joining the 49ers, Isaac Guerendo's rise to significant snaps came in the wake of injuries to star running backs ...

SANTA CLARA, Calif. -- As the first quarter wound down in his second NFL game, San Francisco 49ers running back Isaac Guerendo trotted on to the field, stepped into the huddle and listened ...

And now the spotlight turns to Isaac Guerendo (12 percent rostered on CBS Sports). The rookie from Louisville, who is 6 feet, 221 pounds and runs a 4.33 40-yard dash, will be the No. 1 running ...

Guerendo has averaged an impressive 5.9 yards per carry this season, aided by his ability to break off big runs. On 42 carries, he has totaled 246 rushing yards and two touchdowns, averaging 3.1 ...

So, while Mason will be the top add in fantasy football this week, managers should also be grabbing Isaac Guerendo. The rookie, I would argue, has looked better than Mason when he’s had a chance ...

Both players will be placed on Injured Reserve and will be out for the season. That means rookie Isaac Guerendo will be the starter for the remainder of the season. Guerendo has shown flashes this ...