Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the GI tract. The two major types of IBD are Crohn's disease (CD) and ulcerative colitis (UC). Whereas in UC inflammation ...

APOE4 drove sex-specific changes in meningeal immunity, lymphatic drainage, brain lipids, neuroinflammation, and cognition in mouse models, with females showing greater inflammatory and cognitive ...

Cellular Innate immunity acts as the body's initial defense against pathogens, including viruses. It represents an evolutionarily ancient system, providing rapid but nonspecific responses to a wide ...

Immunology has transformed humanity’s understanding of oneself and its battle against disease. Inflammation which is a primordial defense mechanism against pathogens, also acts as a double-edged sword ...

Researchers at the University of Wisconsin School of Veterinary Medicine have identified a possible way to make ...

Expert Rev Clin Immunol. 2008;4(3):379-390. Since there are no genetic deficiencies of CRP in man, animal models have been used to study the role of CRP in inflammatory disease. Two methods have been ...

" NF-κB is involved in several medically relevant cellular behaviors, such as inflammation, innate immunity and wound healing," Reeves said. "This level of understanding could lead to the ability to ...

TLR4 recognizes bacterial-derived lipopolysaccharides and activates IRF3 via the adapter protein TRIF, contributing to the induction of type I IFN genes. Within endosomes, TLR3, TLR7, and TLR9 ...

Northwestern Medicine investigators have uncovered a missing link behind the harmful effects of autoantibodies linked to ...

Brain tissue analysis of an animal model has revealed the potential role of immune system dysfunction in the onset and progression of Alzheimer's disease (AD). Published April 15, 2025 in the Journal ...

Innate lymphoid cells, which curiously behave like T cells even though they don’t recognize specific antigens, show promise as a potential cancer therapeutic. In the years that followed, other groups ...