Living things have a remarkable ability to function and thrive in a variety of environments that are constantly changing. Despite exposure to wildly different temperatures during heat waves and cold ...

When improperly folded proteins build up in the endoplasmic reticulum (ER), cells become stressed and conditions such as type 2 diabetes, neurodegenerative disorders, and cancers can develop. In a ...

In this Review, we try to provide translational researchers with a simplified but accurate understanding of how energy homeostasis is regulated at the transcriptional level. We introduce the many ...

Scientists have uncovered a powerful ally in the fight against neurodegenerative diseases: a nucleolar complex that plays a pivotal role in maintaining cellular health through protein homeostasis ...

Hepatic lipid homeostasis is critical for both cellular function and overall metabolic health. Disruptions in lipid homeostasis can lead to fatty liver diseases, which have become a significant global ...

Inflammation is a critical component of the immune response that plays a pivotal role in maintaining tissue homeostasis.

Exposure to individual or mixed per- and polyfluoroalkyl substances (PFASs) is associated with changes in peripheral rather than central thyroid hormone sensitivity. PFASs are widely recognized for ...