Nitrogen-containing heteroaromatic-based inhibitors for cytochrome P450 (CYP) in various species contain a crucial coordination between the nitrogen atom and the heme iron. Previous studies suggested ...

The expanded access program (EAP) is available to eligible patients with erythropoietic protoporphyria (EPP) and provides access to bitopertin ...

Red, blue, and yellow lines represent sites for coordination bonds with heme iron, hydrogen bonds with residues, and CH-π bonds, respectively. The red circle marks the site for introducing ...

The biosynthesis of haem is a multi-step enzymatic process that converts simple precursors into the iron-containing tetrapyrrole cofactor essential for oxygen transport, electron transfer and diverse ...

The amino acid glutamine plays an unexpected role in erythropoiesis, the differentiation of erythroid progenitor cells into mature red blood cells. Ordinarily, glutamine is broken down by stem cells ...