Understanding the process of DNA repair, and, importantly, why it fails, holds huge importance as DNA damage is a key factor in many diseases. Critically, many cancer drugs, for example Cisplatin, ...
Targeting highly aggressive ductal prostate tumours with poly ADP ribose polymerase inhibitor (PARPi) and androgen receptor signaling inhibitor (ARSi) combination therapy. This is an ASCO Meeting ...
Every embryo begins with a race against time. Primordial germ cells, the rapidly dividing precursors that ultimately give rise to eggs and sperm, must copy and safeguard their entire genome over and ...
Missed opportunity: PROMs as primary endpoints in bladder cancer trials. This is an ASCO Meeting Abstract from the 2025 ASCO Genitourinary Cancers Symposium. This abstract does not include a full text ...
Genome instability can cause numerous diseases. Cells have effective DNA repair mechanisms at their disposal. A research team has now gained new insights into the DNA damage response. Whenever cells ...
Scientists have discovered that a gene normally considered a DNA-protecting "good guy" can become dangerous when cells make too much of it. The gene, EXO1, acts like molecular scissors that help ...
DNA interstrand crosslinks (ICLs) are highly cytotoxic lesions formed by covalent bonding between opposite DNA strands, obstructing essential processes such as replication and transcription. Repair of ...
A research team has identified the transcription factor C/EBPγ as a novel regulator that simultaneously promotes epithelial-mesenchymal transition (EMT) and DNA double-strand break repair in lung ...
Tyrosyl-DNA phosphodiesterases (TDPs) are specialised enzymes that resolve covalent complexes formed between topoisomerases and DNA during normal cellular processes and in response to genotoxic stress ...
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