We isolated wild-type BHC110 and BHC110 (K661A) mutant complexes using Flag-affinity resin. Analysis of the affinity eluate by SDS–PAGE followed by silver staining and mass spectrometric analysis ...

New research shows that the CoREST complex controls the acquisition of endocrine therapy resistance in estrogen receptor-positive breast cancers. Profiling data show that this resistance transition is ...

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CAMBRIDGE, Mass.--(BUSINESS WIRE)--Rodin Therapeutics today announced the initiation of a Phase 1 clinical trial of the company’s lead candidate, RDN-929, a potent and selective HDAC-CoREST inhibitor.

Left: In wild-type cells, RLF/ZFP292 support the proper function of the CoREST complex, leading to the removal of active histone marks and preventing excessive expression of differentiation-associated ...

IMpactMF, randomized, open-label, phase 3 trial of imetelstat (IME) versus best available therapy (BAT) in patients (pts) with intermediate-2 (INT-2) or high-risk (HR) myelofibrosis (MF) relapsed or ...

Researchers discovered that a protein called CoRest, a neural repressor that is also found in humans, plays a central role in determining the social behavior of ants. The study also revealed that ...

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