Warsaw breakage syndrome (WABS) is caused by defective DDX11, a DNA helicase that is essential for chromatid cohesion. Here, a paired genome-wide siRNA screen in patient-derived cell lines reveals ...

Meiosis is a key event for stable sexual reproduction using a unique form of a cell division to generate haploid recombined gametes. It comprises one round of DNA replication followed by two rounds of ...

Sister chromatid exchanges (SCE) and chromosome aberrations were induced in nondividing CHO cells that had been arrested in their cell cycle by deprivation of the essential amino acid arginine. Cells ...

Scientists reveal a surprising new role for tDNAs and RNA polymerase III-associated proteins in sister chromatid cohesion. Sister chromatid cohesion (the binding together of the two identical copies ...

Since sister chromatids are identical to each other, recombination with a sister chromatid is expected, in most cases, to be a precise way for repairing DNA damage. Recombination between 2 different ...