A major reason for chromatid separation is the precipitous degradation of the cohesin molecules joining the sister chromatids by the protease separase (Figure 10).

Mitotic sister chromatid resolution is thus an intrinsic part of mitotic chromosome formation in prophase that relies largely on DNA decatenation and shares the molecular requirement for ...

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Sister chromatid cohesion is mediated by a multi-subunit protein complex called cohesin. Inside the cell nucleus, cohesin localizes to centromeres (the point of attachment of sister chromatids) ...

Tokyo, Japan – Scientists from Tokyo Metropolitan University have used machine learning to automate the identification of defects in sister chromatid cohesion. They trained a convolutional ...

Johnson's research interests include genetic toxicology, sister chromatid exchange, and behavioral responses in animals to hormonal and chemical stimuli. Started at Bethel. 1975. Education. Bethel ...

Since sister chromatids are identical to each other, recombination with a sister chromatid is expected, in most cases, to be a precise way for repairing DNA damage. Recombination between 2 different ...

DNA breaks are toxic lesions for the cell. In order to repair these breaks, it is necessary, starting from the break ends, to ...

Scientists from Tokyo Metropolitan University have used machine learning to automate the identification of defects in sister chromatid cohesion. They trained a convolutional neural network (CNN ...